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In patients who have new or worsening respiratory symptoms and are suspected to have developed pneumonitis, interrupt IBRANCE immediately and evaluate the patient. New York, NY: Garland Science; 2014:275-329. IBRANCE when taken in combination with an aromatase inhibitor as initial endocrine based therapy in postmenopausal women or in men; or with fulvestrant in patients with disease progression following endocrine therapy. Across clinical trials (PALOMA-1, PALOMA-2, PALOMA-3), 1. Grade 3 or 4, and no fatal cases were reported.

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